… Our aim was to test associations between genetic polymorphisms involved in the absorption
and metabolism of CsA and TAC, and drug disposition variables in two groups of Chilean …

… data obtained from Spanish Caucasians, particularly from the northern region of Spain and
to the … Influence of genotype and haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the …

… The human MDR1 gene mutation at exon 26, position 3435 (also known as C3435T) leads
… Although the C3435T mutation in exon 26 of the MDR1 gene is a silent mutation, this poly‑ …

… The present meta-analysis is performed to determine the association of C1236T and
C3435T polymorphisms in the MDR1 gene. Google Scholar, PubMed, and Science Direct were …

… the contribution of the C3435T polymorphism to disease risk in … the single nucleotide
polymorphism (SNP) C3435T by using the … (Spain) found a significant association between the …

… Of these three SNPs, C1236T and C3435T are silent polymorphisms. While C1236T does
not affect protein expression or mRNA stability, altered mRNA, and protein expression levels …

… three ABCB1 common polymorphisms (ie, C3435T, or rs1045642… The protocol complied with
current Spanish legislation on … human MDR1 drug efflux transporter and genetic variation of …

… ABCB1 common polymorphisms (ie, C3435T, or … Spanish legislation on clinical research
in humans and was approved by the Research Ethics Committee, authorized by the Spanish …

… Our results indicated that C3435T polymorphisms did not affect PFS and OS, whereas …
The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-…

… -gp to human variability is the impact of polymorphic genotypes on kinetics, although few
studies … The MDR1 gene is highly polymorphic and several SNPs have been identified, among …